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KMID : 0828520010050010050
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Journal of the Korean Geriatrics Society
2001 Volume.5 No. 1 p.50 ~ p.55
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Cerebrospinal Fluid Aspartate Aminotransferase in Alzheimer Disease and Vascular Dementia
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Abstract
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Background : To evaluate usefulness of cerebrospinal aspartate aminotransferase(AST) as a biologic marker for differentiation of Alzheimer´s disease(AD) and Vascular dementia(VD)
Methods : A consecutive series of patients who met either the criteria of the National Institute of Neurological Disorders and Stroke and the Alzheimer´s Disease and Related Disorders Association(NINCDSADRDA) for probable AD or National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et l´Enseignement en Neurosciences(NINDS-AIREN) criteria for porbable VD were included in the study. Enzymatic determinations in cere brospinal fluid of aspartate aminotransferase in cerebrospinal fluid of aspartate aminotransferase and serologic analysis of apolipoprotein E were performed in 17 patients with AD and in 15 patients with VD. And we compared CSF AST of AD with that of VD.
Results : We found no difference of CSF AST concentration between patients with Alzheimer´s disease and vascular dementia. Cerebrospinal AST activity also did not correlate with K-MMSE score, serum AST activity, Functional inde- pence measure(FIM) as a ADL(Activity of daily living), and presence of Apolipoprotein E4 allele in AD. Only serum AST of VD shows correlation with CSF AST.
Conclusion : These findings suggest that cerebrospinal AST concentration is not useful maker for differentiation between AD and VD.
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